Spurs had Xavi Simons sent off just past the half-hour mark and Isak then broke the deadlock in the capital with a 56th-minute finish.
Ekitike’s header 10 minutes later – his fifth goal in his last three league outings – was enough to secure the points for the Reds, who held on after Richarlison netted late in the second half.
The hosts went down to nine men in stoppage time after Cristian Romero was guilty of a second bookable offence.
Team
Conor Bradley returned from suspension as the only change to the line-up Liverpool deployed against Brighton & Hove Albion the previous weekend.
Jeremie Frimpong started on the bench after recovering from the injury he sustained in October.
Liverpool: Alisson, Van Dijk, Konate, Kerkez, Wirtz (Nyoni, 90+9), Szoboszlai, Mac Allister, Bradley (Isak, 46 (Frimpong, 60 (Chiesa, 90))), Jones, Ekitike (Robertson, 90+9), Gravenberch.
Unused subs: Mamardashvili, Ramsay, Ngumoha, Lucky.
