This is the ninth successive season that the Reds have faced Italian opposition.
Dominik Szoboszlai and Virgil van Dijk have played every minute of Liverpool’s Champions League campaign this season.
Conor Bradley will be suspended for the trip to Marseille in the New Year if he is booked in this match.
The Reds have lost only twice in their last 16 games played on December 9, a sequence going back to 1933 – against Fiorentina in 2009 and in 1984 versus Independiente in the World Club Championship in Tokyo.
Inter were the last Italian Champions League winners, lifting the trophy in 2010 when they defeated Bayern 2-0 in Madrid.
The Nerazzurri reached the European Cup final in two of the past three seasons but lost on both occasions – against Manchester City in 2023 and Paris Saint-Germain earlier this year.
They have won four of their five fixtures in the Champions League so far this term, conceding only three goals.
