Giorgi Mamardashvili is named in goal, while there are starts for Joe Gomez and Andy Robertson in defence.
Elsewhere, Federico Chiesa, Curtis Jones and Rio Ngumoha also come into the Reds XI for the third-round fixture.
Hugo Ekitike and Wataru Endo return to the squad after respective injury issues and are on the bench.
Liverpool: Mamardashvili, Gomez, Van Dijk, Szoboszlai, Mac Allister, Chiesa, Jones, Gakpo, Robertson, Frimpong, Ngumoha.
Subs: Alisson, Endo, Konate, Kerkez, Wirtz, Ekitike, Gravenberch, Nyoni, Ramsay.
